Kim Kardashian and Adrienne Bailon and good friends. They often hang out, go to dinner, exchange naked picture advice with each other. Good times are often had all around... but that won't be the case today. Although each beauty accessorized the following outfit with a different belt, Kim and Adrienne still donned the same dress to public events over the last few weeks. That means it's time for another fashion face-off, where even the tightest friends become sworn red carpet enemies...
Jessica Simpson squeezed into a little black dress - one of her own - on Wednesday to launch her new Jessica Simpson Collection at Macy's in New York City. During the two-hour store appearance, she signed autographs and greeted fans, whom she had earlier invited (via Twitter) to wear articles from her line. With boyfriend Eric Johnson in tow, she said: "What a great night!!! Thanks to everyone for coming out." What do you think of her dress?
Rihanna and Jennifer Garner are not two celebs you often associate with the similar fashion sense ... or each other, period. But we're THG. We break down barriers. The singer strutted out of her N.Y.C. hotel rocking Stella McCartney's sheer-topped dress, while the actress wore the very same item at the Toronto Film Festival. The question is who wore it best?
When most of us catch a flight at LAX, we don't show up in our finest weave, panties, fishnets, "Solid Gold" dancer jacket, handcuffs, 12-inch heels and little else. Then again, Miss Lady Gaga is not most of us. When you're a pop star, style icon and rumored hermaphrodite, you do what you want - and always make a statement. Hey, at least it's not a meat dress ...
Ashley Greene stars in Breaking Dawn, while Bethenny Frankel is up at dawn every morning to feed her baby daughter. Okay. We give up. These two celebrities have very little in common, except for this: both walked the white carpet at last night's MTV Video Music Awards. Greene looked unusually perturbed to be there, while Frankel posed with a big smile on her face, likely wondering: What the heck did I do to earn a spot on this guest list?!? Choose between the pair below:
Nicki Minaj. Jenna Jameson. Not names you normally associate with one another, but only the MTV Video Music Awards bring together so many random celebs! The rapper, who made headlines earlier this summer with her non-wedding to Drake, raised eyebrows with a wig that would make Rihanna or Lady Gaga proud. The adult film queen, meanwhile, stepped out for one of her first appearances since the Tito Ortiz assault scandal earlier this year. She looked terrific, and happy!
Few fashion statements could realistically the thunder of Lady Gaga's meat dress at last night's MTV Video Music Awards, but Cher certainly tried her best. Presenting Gaga with the Video of the Year honor, Cher graced the Nokia Theater stage in a bodysuit reminiscent of her "If I Could Turn Back Time" video. That video was filmed in 1989. Cher is now 64 years old. Still, she rocks it pretty darn well. Seeing the music icon in this makes us ponder the obvious:
Combining eccentric style and natural beauty, Katy Perry is always a fashion favorite of ours, but Stephanie Pratt may actually give her a run for her money here. With highlights and a creatively patterned and not-too-revealing dress (for her), Katy looks adorable. Stephanie, meanwhile, went for a classier, traditional look. That's the first-ever use of "Stephanie Pratt" and "classier" in the same sentence. If she weren't the sister of Spencer Pratt, we ... forget it. Who looked best?
We profiled the men of Jersey Shore and their collective abundance of hair gel earlier today. Now it's a style showdown featuring a pair of their female co-stars. Looking like an extra from Willy Wonka and the Chocolate Factory, Nicole "Snooki" Polizzi showed us why she doesn't check off "white" on job applications. Sammi Giancola, meanwhile, may not live up to her "Sweetheart" nickname on the show, but she looks sweet in the photo below. Who looked better?
A very special episode of Jersey Shore preceded Sunday night's MTV Video Music Awards. Then its cast members made a special appearance on the white carpet. When it comes to style, Ronnie Magro, Mike Sorrentino (The Situation) and Paul DelVecchio (Pauly D) certainly have their own. And industrial quantities of gel. Which star looked best (or least bad) last night? Vote below!
Su Qi-Er, a wealthy man living during the Qing Dynasty who loses his fortune and reputation as a result of a conspiracy against him. After being forced out onto the streets, Su dedicates his life to martial arts and reemerges as a patriotic hero known as the "King of Beggars."
[Chorus] I’m not afraid to take a stand Everybody come take my hand We’ll walk this road together, through the storm Whatever weather, cold or warm Just let you know that, you’re not alone Hola if you feel that you’ve been down the same road
[Intro] Yeah, It’s been a ride… I guess i had to go to that place to get to this one Now some of you might still be in that place If you’re trying to get out, just follow me I’ll get you there
[Verse 1] You can try and read my lyrics off of this paper before I lay ‘em But you won’t take the sting out these words before I say ‘em Cause ain’t no way I’m let you stop me from causing mayhem When I say ‘em or do something I do it, I don’t give a damn What you think, I’m doing this for me, so f-ck the world Feed it beans, it’s gassed up, if a thing’s stopping me I’mma be what I set out to be, without a doubt undoubtedly And all those who look down on me I’m tearing down your balcony No if ands or buts don’t try to ask him why or how can he From Infinite down to the last Relapse album he’s still sh-t and Whether he’s on salary, paid hourly Until he bows out or he sh-t’s his bowels out of him Whichever comes first, for better or worse He’s married to the game, like a f-ck you for Christmas His gift is a curse, forget the earth he’s got the urge To pull his d-ck from the dirt and f-ck the whole Universe
[Chorus]
[Verse 2] Ok quit playin’ with the scissors and sh-t, and cut the crap I shouldn’t have to rhyme these words in the rhythm for you to know it’s a rap You said you was king, you lied through your teeth For that f-ck your feelings, instead of getting crowned you’re getting capped And to the fans, I’ll never let you down again, I’m back I promise to never go back on that promise, in fact Let’s be honest, that last Relapse CD was “ehhhh” Perhaps I ran them accents into the ground Relax, I ain’t going back to that now All I’m tryna say is get back, click-clack BLAOW Cause I ain’t playin’ musicjuzz.blogspot.com around There’s a game called circle and I don’t know how I’m way too up to back down But I think I’m still tryna figure this crap out Thought I had it mapped out but I guess I didn’t This f-cking black cloud’s still follow’s me around But it’s time to exercise these demons These motherfu-kers are doing jumping jacks now!
[Chorus]
[Bridge] And I just can’t keep living this way So starting today, I’m breaking out of this cage I’m standing up, Imma face my demons I’m manning up, Imma hold my ground I’ve had enough, now I’m so fed up Time to put my life back together right now
[Verse 3] It was my decision to get clean, I did it for me Admittedly I probably did it subliminally for you So I could come back a brand new me, you helped see me through And don’t even realise what you did, believe me you I been through the ringer, but they can do little to the middle finger I think I got a tear in my eye, I feel like the king of My World, haters can make like bees with no stingers, and drop dead No more beef flingers, no more drama from now on, I promise To focus solely on handling my responsibility’s as a father So I solemnly swear to always treat this roof like my daughters and raise it You couldn’t lift a single shingle on it Cause the way I feel, I’m strong enough to go to the club Or the corner pub and lift the whole liquor counter up Cause I’m raising the bar, I shoot for the moon But I’m too busy gazing at stars, I feel amazing and
[Chorus] I’m not afraid to take a stand Everybody come take my hand We’ll walk this road together, through the storm Whatever weather, cold or warm Just let you know that, you’re not alone Holla if you feel that you’ve been down the same road
[Sean Kingston] Eenie meenie miney mo Catch a bad chick by her toe If she holla (if, if, if she holla) let her go She’s indecisive She cant decide She keeps on lookin From left to right Girl, cmon get closer Look in my eyes Searchin is so wrong Im Mr. Right You seem like the type To love em and leave em And disappear right after this song. So give me the night To show you, hold you Dont leave me out here dancin alone You cant make up your mind, mind, mind, mind, mind Please dont waste my time, time, time, time, time Im not tryin to rewind, wind, wind, wind, wind I wish our hearts could come together as one Cause shorty is a eenie meenie miney mo lova Shorty is a eenie meenie miney mo lova Shorty is a eenie meenie miney mo lova Shorty is a eenie meenie miney mo lova [Justin Bieber] Let me show you what your missin Paradise With me you’re winning girl You don’t have to roll the dice Justin Bieber Eenie Meenie Tell me what you’re really here for Them other guys? I can see right through ya You seem like the type To love em and leave em And disappear right after the song. So give me the night To show you, hold you Dont leave me out here dancin alone Cant make up your mind Please dont waste my time Not tryin to rewind I wish our hearts could come together as one Cause shorty is a eenie meenie miney mo lova Shorty is a eenie meenie miney mo lova Shorty is a eenie meenie miney mo lova Shorty is a eenie meenie miney mo lova [Sean Kingston] Eenie meenie miney moe Catch a bad chick by her toe If she holla (if, if, if she holla) let her go Eenie meenie miney moe Catch a bad chick by her toe If she holla (if, if, if she holla) let her go Shorty is a eenie meenie miney mo lova Shorty is a eenie meenie miney mo lova Shorty is a eenie meenie miney mo lova Shorty is a eenie meenie miney mo lova Cant make up your mind Please dont waste my time Not tryin to rewind I wish our hearts could come together as one (repeat) [End]
See I never thought that I could walk through fire. I never thought that I could take the burn. I never had the strength to take it higher, Until I reached the point of no return.
And there’s just no turning back, When your hearts under attack, Gonna give everything I have, It’s my destiny.
I will never say never! (I will fight) I will fight till forever! (make it right) Whenever you knock me down, I will not stay on the ground. Pick it up, Pick it up, Pick it up, Pick it up up up, And never say never.
I never thought I could feel this power. I never thought that I could feel this free. I’m strong enough to climb the highest tower. And I’m fast enough to run across the sea. source http://www.justinbieberzone.com
And there’s just no turning back, When your hearts under attack, Gonna give everything I have, Cause this is my destiny.
I will never say never! (I will fight) I will fight till forever! (make it right) Whenever you knock me down, I will not stay on the ground. Pick it up, Pick it up, Pick it up, Pick it up, up, up, And never say never.
Here we go! Guess who? JSmith and Jb! I gotcha lil bro. source http://www.justinbieberzone.com I can handle him. Hold up, aight? I can handle him.
Now he’s bigger than me, Taller than me. And he’s older than me, And stronger than me. And his arms a little bit longer than me. But he ain’t on a JB song with me!
I be trying a chill They be trying to side with the thrill. No pun intended, was raised by the power of Will.
Like Luke with the force, when push comes to shove. Like Cobe with the 4th, ice water with blood.
I gotta be the best, and yes We’re the flyest. Like David and Goliath, I conquered the giant. So now I got the world in my hand, I was born from two stars So the moon’s where I land.
I will never say never! (I will fight) I will fight till forever! (make it right) Whenever you knock me down, I will not stay on the ground. Pick it up, Pick it up, Pick it up, Pick it up, up, up, And never say never.
I will never say never! (I will fight) I will fight till forever! (make it right) Whenever you knock me down, I will not stay on the ground. Pick it up, Pick it up, Pick it up, Pick it up, up, up, And never say never.
Read more: Justin Bieber ft. J. Smith – Never Say Never LYRICS + Video | Justin Bieber Zone http://www.justinbieberzone.com/2010/05/justin-bieber-ft-j-smith-never-say-never-lyrics-video/#ixzz0rnqXOnSt
Justin Bieber] Oh woooah, oh woooooah, oh wooooah, oh. You know you love me, I know you care, Just shout whenever and I’ll be there. You are my love, you are my heart and we will never ever ever be apart. Are we an item? girl quit playing, we’re just friends, what are you saying. Said there’s another, look right in my eyes, my first love broke my heart for the first time. And I was like…
[Chorus] Baby, baby, baby oooooh, like baby, baby, baby noooooooo, like baby, baby, baby, ooooh. Thought you’d always be mine, mine (repeat)
[Justin Beiber] Oh, for you I would have done whatever, and I just can’t believe we aint together and I wanna play it cool, but I'm losing you I'll buy you anything, I'll buy you any ring, And I'm in pieces, baby fix me and you shake me til’ you wake me from this bad dream. I’m going down down down down and I just can’t believe my first love won’t be around. And I’m like…
[Chorus]
[Ludacris] Luda, When I was 13 I had my first love, there was nobody that compared to my baby and nobody came between us, no-one could ever come above She had me going crazy, oh I was star-struck, http://www.elyricsworld.com/baby_(feat._ludacris)_lyrics_justin_bieber.html she woke me up daily, don’t need no Starbucks. She made my heart pound, I skip a beat when I see her in the street and at school on the playground but I really wanna see her on the weekend. She knows she got me dazing cause she was so amazing and now my heart is breaking but I just keep on saying….
[Justin Bieber] Ohh Ohh For you I’d write a symphony I’d tell the violin It’s time to sink or swim Watch him play for ya For you I’d be (Whoa) Runnin a thousand miles Just get you where you are Step to the beat of my heart. I don’t need a whole lot But for you I need I Rather give you the world Or we can share mine I know that I won’t be the first one Given you all this attention But baby listen I just need somebody to love I-I don’t need too much Just need somebody to love. (Somebody to love) I don’t need nothing else I promise girl, I swear. I just need somebody to love. I need somebody I-I need somebody I need somebody I-I need somebody.
[Usher] Everyday I bring the sun around I sweep away the clouds. Smile for me (Smile for me) I would take Every second, every single time Spend it like my last dime. Step to the beat of my heart. I don’t need a whole lot But for you I need I Rather give you the world Or we can share mine I know I won’t be the first one Given you all this attention But baby listen
She puts her makeup on Like graffiti on the walls of the heartland She's got her little book of conspiracies Right in her hand She is paranoid like Endangered species headed into extinction She is one of a kind Well She's the last of the American girls
She wears her overcoat For the coming of the nuclear winter She is riding her bike Like a fugitive of critical mass She's on a hunger strike For the ones who won't make it for dinner She makes to enough to survive For a holiday of working class
She's a runaway of the establishment incorporated. She won't cooperate Well She's the last of the American girls
She plays her vinyl records Singing songs on the eve of destruction She's a sucker for All the criminals breaking the laws She will come in first For the end of western civilization She's an endless war She's a hero for the lost cause Like a hurricane In the heart of the devastation She's a natural disaster She's the last of the American girls
She puts her makeup on Like graffiti on the walls of the heartland She's got her little book of conspiracies Right in her hand She will come in first For the end of western civilization She's a natural disaster She's the last of the American girls
Come waste your millions here, secretly she sneers Another corporate show, a guilty conscience grows
I'll feel a guilty conscience grow And I'll feel a guilty conscience grow
She burns like the sun, and I can't look away She'll burn our horizons, make no mistakes
Come let the truth be shared, no one ever dared To break these endless lies, secretly she cries
She burns like the sun, and I can't look away And She'll burn our horizons, make no mistakes
I'll hide from the world behind a broken frame And I'll burn forever, I can't face the shame And I'll hide from the world behind a broken frame And I'll burn forever, I can't face the shame
Shame on you For thinking you're an exception We're all to blame Crashing down to Earth Wasting and burning out, you're Fading like a dead star, woah Harm is coming your way Yeah, it's coming your way
You used to be everything to me And now you're tired of fighting Tired of fighting Fighting yourself
Shame on you For thinking You're all alone If you want I'll make you wish you were Failing to impress Why can't you sleep with Someone who'll protect you, yeah Harm is coming your way Yeah it's coming your way
You used to be everything to me And now you're tired of fighting Tired of fighting Fighting yourself
Oh baby don't you know I suffer? Oh baby can't you hear me moan? You caught me under false pretences How long before you let me go?
oooh...You set my soul alight oooh...You set my soul alight
(oooh...You set my soul alight) Glacier's melting in the dead of night And the superstars sucked into the supermassive
(oooh...You set my soul alight) Glacier's melting in the dead of night And the superstars sucked into the supermassive
I thought I was a fool for no-one Oh baby I'm a fool for you You're the queen of the superficial And how long before you tell the truth
oooh...You set my soul alight oooh...You set my soul alight
(oooh...You set my soul alight) Glacier's melting in the dead of night And the superstars sucked into the supermassive
(oooh...You set my soul alight) Glacier's melting in the dead of night And the superstars sucked into the supermassive (sucked into the supermassive)
Supermassive black hole Supermassive black hole Supermassive black hole Supermassive black hole ohhhhhhhhh ohhhhhhhh Glaciers melting in the dead of night And the superstars sucked into the supermassive
Glaciers melting in the dead of night And the superstars sucked into the supermassive
(oooh...You set my soul alight) Glacier's melting in the dead of night And the superstars sucked into the supermassive
(oooh...You set my soul) Glacier's melting in the dead of night And the superstars sucked into the supermassive
Supermassive black hole Supermassive black hole Supermassive black hole Supermassive black hole
What originally inspired this song was Pierre's brother's battle with cancer. About 3 years ago, Jay was diagnosed with non-Hodgkin's lymphatic cancer. After 2 years of extremely difficult chemotherapy treatments, he learned that the cancer was gone for now and that he was in remission. After being told he had a 50-50 chance to come out of this alive, he had won his battle.
Because this happened to someone so close to us, we felt that, as a band, we had to do something to help. We had to get involved and use our voice to make a difference in the fight against cancer.
We wanted this video to tell his story and the ones of all cancer survivors. We want to show how strong people can be when facing adversity and hardship and how resilient the human mind and body can be. We wanted to relay a message of hope, survival and courage.
With the assistance of iTunes, Lava/Atlantic, and Warner/Chappell Music, all proceeds from each downloaded sale will be distributed to cancer charities around the world, through the Simple Plan Foundation. "Save You" - which is also found on our self-titled third studio album "Simple Plan" - can be purchased on iTunes.
Pleural mesothelioma may also be referred to as ICD-9 code 163, a disease category that represents malignant neoplasm of the pleura. Peritoneal mesothelioma may be called ICD-9 code 158, which accounts for malignant neoplasm of the retroperitoneum and peritoneum. Pericardial mesothelioma falls under the category ICD-9 code 164, which represents malignant neoplasm of the thymus, heart and mediastinum. Asbestos.com provides a list of treatment options catered to your specific diagnosis. For an informational packet with a detailed list of these options and additional literature about mesothelioma, please fill out this form or call 800-272-3786.
Regardless of the type of malignant mesothelioma a patient has, treatment options are available for all mesothelioma patients, though a patient’s response to different treatments will vary. The stage , or level of maturity of the cancer, as well as the patient’s general health are greatly considered when a doctor creates a treatment plan. Common curative treatments, or treatments designed to remove cancer cells and cure the disease, for mesothelioma patients include surgery, chemotherapy and radiation. Chemotherapy and radiation treatments aim to kill cancerous cells and stop rapid cell division and growth. Though harmful cells are targeted, the treatments can also affect healthy cells. Patients may experience side effects such as nausea throughout treatment. Palliative treatments, designed to increase a patient’s comfort and ease pain, may also be recommended. Patients may also wish to explore experimental treatments offered in the studies testing up-and-coming drugs or procedures called clinical trials.
In biological terms, malignant mesothelioma is divided into three types: epithelial, sarcomatoid and biphasic. These classifications pertain to the shape and structure of the cancer cells.
Diagram of Malignant Mesothelioma Types.
Between 50 to 70 percent of malignant mesothelioma cases are epithelial, approximately 20 to 35 percent are biphasic, and 7 to 20 percent are sarcomatoid. Epithelial cells are marked by their well-defined and uniform shape and can closely resemble cells of another form of cancer known as adenocarcinoma. Sarcomatoid cells display an elongated spindle shape, which tend to be irregular rather than uniform in shape, and the cells often overlap one another. Cells of the biphasic variety contain both epithelial and sarcomatoid cells, which form in groups of like cells rather than displaying a uniform mixture. Diagnosing what type of malignant mesothelioma a patient has can be challenging. One contributing factor is that it can be difficult to differentiate mesothelioma from adenocarcinoma, a cancer originating in glandular tissue, on small tissue specimens.
Patients with malignant mesothelioma generally do not display any symptoms until 20 to 50 years after exposure to asbestos occurs. This is due to the long latency period (the amount of time it takes for a patient to demonstrate symptoms after initial exposure to a disease-causing agent) associated with mesothelioma. The symptoms of mesothelioma are very general and often resemble less serious conditions, which can make diagnosis difficult. Symptoms vary depending on the type of mesothelioma a patient has, but the most common symptoms expressed by pleural mesothelioma patients include shortness of breath, chest pain and persistent cough. Peritoneal mesothelioma patients may display symptoms such as abdominal swelling, changes in bowel movement and development of lumps under the skin on the abdomen. Patients with pericardial mesothelioma may experience heart palpitations, chest pain, difficulty breathing and fever or night sweats. Testicular mesothelioma patients may notice testicular lumps. Asbestos.com offers a complimentary informational packet personalized to a patient’s specific mesothelioma diagnosis. With information about the cancer, treatment options and top doctors, many patients and their loved ones find the packet to be a valuable resource. Click here for more information or to receive your complimentary packet overnight.
Malignant mesothelioma is a form of asbestos cancer that affects the thin tissue layer surrounding the body's internal organs, called the mesothelium. The cancer is almost exclusively caused by asbestos exposure. In an effort to help patients understand mesothelioma, Asbestos.com offers a complimentary packet that contains treatment information tailored to your specific diagnosis. The packet also covers the nation's top mesothelioma doctors and cancer centers, as well as financial assistance options to help cover medical costs. To receive your packet in the mail, please enter your information below.
A number of studies have been conducted on the specifics of the length of latency periods among those exposed to asbestos. In the case of mesothelioma, evidence has indicated that high exposure for short periods of time might be more damaging than low exposure for many years. For example, Deborah Reeve, a New York City paramedic and first responder at the site of the World Trade Center attacks in 2001, passed away from mesothelioma in 2006, just five years after her exposure to asbestos from the events on September 11. Deborah had symptoms of the disease as early as 2003 and was diagnosed with mesothelioma in 2004. Numerous studies on asbestosis agree that more than 90 percent of individuals who were exposed to asbestos for 40 years or more will develop the disease. For those who worked with the toxic mineral for 20-30 years, the rate is about 75 percent. Those who experienced 10-19 years of exposure have an incidence level of about 10 to 15 percent. These numbers may also vary according to the level of asbestos someone is exposed to on a daily basis. For example, shipbuilders of the mid-20th century were nearly always surrounded by asbestos as were many construction workers. Those groups have tended to develop asbestosis sooner than those who worked in other industries where the levels may not have been as high. Patients concerned about the latency period associated with mesothelioma and the possibility of developing the cancer may be interested to read more about mesothelioma symptoms. Sources:
The term latency period is used to describe the period of time between exposure to a potential disease-causing agent and the time the disease becomes apparent. According to most experts, in the case of mesothelioma the latency period ranges from 20 to 50 years after initial exposure to asbestos occurred, though there have been instances when the time period was shorter or longer. Due to the long latency period associated with the cancer, those exposed to asbestos during the 1950s, '60s and '70s are beginning to demonstrate mesothelioma symptoms today, decades after they were exposed to asbestos.
While no one should spend their days dwelling on the fact that they could someday develop an asbestos-related disease, there are some things that can be done to aid in early diagnosis if mesothelioma is indeed present. The most notable development in the last few years is the mesothelioma blood test known as Mesomark. Approved by the FDA in 2007, this simple test measures a particular cancer biomarker and can catch mesothelioma in the early stages of development. The blood test is not available everywhere but if you wish to undergo testing, asking your doctor where you may take advantage of the test may aid in early detection. Those exposed to asbestos run the risk of developing asbestosis or mesothelioma and may wish to schedule yearly chest X-rays to check for any suspicious signs of disease. If a doctor determines there may be a concern after the X-ray, further imaging tests such as CT scans or MRIs may be recommended. A biopsy may also be requested to test for the presence of cancerous cells. Asbestos.com offers additional information about mesothelioma diagnosis, treatment and top doctors though a complimentary comprehensive packet. Please click here to receive your copy.
Today's most commonly used chemotherapy medication for mesothelioma is Alimta. Currently, this drug is the only FDA-approved medication specifically designed for the treatment of malignant mesothelioma when surgery is not an option. It is generally used in combination with another chemotherapy drug called cisplatin, a platinum-based drug. Together, the two have shown promise in prolonging and improving the quality of life of mesothelioma patients. Other chemotherapy drugs sometimes used for mesothelioma treatment include carboplatin, onconase, gemcitabine, and navelbine.
Most mesothelioma patients' drug regimens are not limited to chemotherapy medications. It is often necessary to take other medications to help combat the symptoms and side effects of the disease. Those who take the time to find the right combination of pain medications indicate a marked difference in their quality of life. However, patients should never take pain medications without consulting their doctor. In some cases, doctors will also recommend the use of anti-nausea drugs for chemotherapy patients. Anti-nausea drugs for nausea include Compazine, Torecan, Zofran and Kytril.
Chemotherapy medications have been used to treat cancer since the 1950s. Many of the older ones are obsolete and have been replaced by newer, more successful drugs. An oncologist will determine which chemotherapy medication is best for you. In addition to chemotherapy, surgery or radiation may also be recommended. Chemotherapy can be administered at a hospital, doctor's office, or in a clinic setting that caters only to cancer patients. Such treatment is most commonly administered intravenously through a catheter or directly into a vein. Some chemotherapy medications come in pill or liquid form and will be swallowed under the supervision of a doctor. Others can be taken at home following the strict instructions of a medical professional. The dosage of the medication will be determined by your doctor and may include daily treatments for a specific time. Though chemotherapy can be very helpful, it can carry a number of side effects. Some mesothelioma patients will experience none at all while others may be shouldered with several uncomfortable side effects. These include nausea, vomiting, fatigue, loss of appetite, weight loss, hair loss, bruising or bleeding, and an increased susceptibility to infection.
A diagnosis of mesothelioma will normally be followed by several discussions with your oncologist. Such topics of discussion will cover prognosis and treatment options to battle the disease. More often than not, the course of treatment can include a variety of mesothelioma medications.
Heated chemotherapy is only a treatment option for patients with peritoneal mesothelioma. Those coping with mesothelioma of the pleura or pericardium will need to explore other treatment options with their cancer doctor. Patients eligible for heated chemotherapy will be informed by their doctor and will need to discuss treatment options extensively before determining whether this is a good option.
There are two particularly important features of heated chemotherapy that make this a superior alternative to standard chemotherapy. First, the chemotherapeutic medications are applied directly to the affected site. This means the medications are in direct contact with tissues that are affected by mesothelioma. In traditional chemotherapy, the patient is treated with chemotherapeutic medications intravenously and the patient's entire body is affected by the medications. Injecting chemotherapeutic agents directly into the peritoneum increases their concentration at the cancer site and causes less serious side effects than traditional chemotherapy treatments. The second important feature is the heating of the medications to the approximate temperature of the human body. Heating the chemotherapeutic agents increases their ability to penetrate tissues. This is vital because traditional chemotherapy treatments do not always effectively penetrate dense tumors.
Heated chemotherapy for peritoneal mesothelioma, which is also known as heated intraoperative intraperitoneal chemotherapy, is administered in a very different fashion than most other types of chemotherapy. During the heated chemotherapy procedure, a patient is treated with chemotherapeutic medications in liquid form that are administered directly into the peritoneum (the lining of the abdominal cavity). Before this can take place, patients undergo surgery that removes as much of the tumors growing in the peritoneum as possible. Once the surgical procedure has been completed, chemotherapy can begin. During this part of the treatment, the patient's peritoneum is permeated with heated chemotherapeutic medications to expose all organs and tissues within the peritoneum in a uniform fashion (this ensures all affected organs receive treatment). The chemotherapeutic medications used in the procedure are heated to a temperature between 44 - 46 °C (111-114 F°), and the intraperitoneal environment is maintained at a temperature of approximately 42 - 43 °C (107-109 F°). The chemotherapeutic fluid is perfused in the peritoneum for one to two hours and then drained from the operation site.
intravenously, typically once a week or once every three or four weeks (length of time is determined by the patient's physician). There are several common chemotherapeutic medications that may be used to treat mesothelioma, including Alimta, Cisplatin, and Carboplatin. However, a new form of chemotherapy is being tested in clinical trials involving mesothelioma patients. This treatment, known as heated chemotherapy, is showing some promise for the treatment of peritoneal mesothelioma, a form of mesothelioma that attacks the protective lining around the abdomen. (Due to the nature of the treatment, it has been deemed inappropriate for pleural and pericardial mesothelioma.) This treatment was developed by Paul Sugarbaker at the Washington Cancer Institute, and is commonly referred to as the Sugarbaker technique.
Deciding which chemotherapy option is the best treatment for specific mesothelioma cases depends on a number of factors, including the type of mesothelioma, the stage of the disease, and other treatment being administered. Factors such as overall physical health and age are also taken into consideration when detailing a chemotherapy treatment plan. Currently more than 100 chemotherapy drugs are on the market but only a handful are deemed appropriate for fighting mesothelioma. In most cases, doctors treating mesothelioma patients recommend combination therapy - the tandem use of two different chemotherapy drugs. These combinations have been proven to be the most successful in the fight against mesothelioma. . All treatment options will be thoroughly discussed with the patient's cancer doctor before a decision is made. Patients should provide a full disclosure of their medical history, including details of any prescriptions and over-the-counter medications being taken to ensure treatment is administered with the most appropriate chemotherapeutic agent. Currently, the most common chemotherapy drugs for mesothelioma include Alimta (the only FDA-approved drug specifically designed for the treatment of mesothelioma), Cisplatin, Carboplatin, Onconase, Gemcitabine, and Navelbine. The medications are usually administered conventionally (by IV or pill form), or may be used in a newer treatment method called heated chemotherapy.
Currently, there is no proven cure for mesothelioma. However, chemotherapy can help control symptoms and shrink tumors and is largely used as a palliative measure to help improve the patient's quality of life. The development of combination treatments has proved successful in achieving longer survival rates and researchers continue to look for new ways to fight this aggressive disease. If you or a loved one have been diagnosed with mesothelioma, you may find solace in reading “Lean on Me – Cancer through a Carer’s Eyes,” a touching story by Lorraine Kember who recounts her husband’s journey with mesothelioma in this emotional and informative book. For your complimentary copy, please use this form or visit the “Support Book” link to the right for more information. Sources:
Dodson, R. and Hammar, S. Asbestos: Risk Assessment, Epidemiology, and Health Effects. Taylor & Francis: Boca Raton. 2006.
Galateau-Salle, Francoise. Pathology of Malignant Mesothelioma. Springer-Verlag London Limited: London. 2006.
Pass, I., Vogelzang, N., Carbone, M. Malignant Mesothelioma: Advances in Pathogenesis, Diagnosis, and Transitional Therapies. Springer: New York. 2005.
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