Heated chemotherapy for peritoneal mesothelioma, which is also known as heated intraoperative intraperitoneal chemotherapy, is administered in a very different fashion than most other types of chemotherapy.
During the heated chemotherapy procedure, a patient is treated with chemotherapeutic medications in liquid form that are administered directly into the peritoneum (the lining of the abdominal cavity). Before this can take place, patients undergo surgery that removes as much of the tumors growing in the peritoneum as possible.
Once the surgical procedure has been completed, chemotherapy can begin. During this part of the treatment, the patient's peritoneum is permeated with heated chemotherapeutic medications to expose all organs and tissues within the peritoneum in a uniform fashion (this ensures all affected organs receive treatment).
The chemotherapeutic medications used in the procedure are heated to a temperature between 44 - 46 °C (111-114 F°), and the intraperitoneal environment is maintained at a temperature of approximately 42 - 43 °C (107-109 F°). The chemotherapeutic fluid is perfused in the peritoneum for one to two hours and then drained from the operation site.
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